Next, we analyzed whether the combined expression of three therapeutic genes translate to more potent antitumor effect than oncolytic Ad expressing either RLX alone (oAd/RLX)13 20 or coexpressing IL-12 and GM-CSF (oAd/IL12/GM)21 in a Syrian hamster syngeneic pancreatic tumor model. Here, CSF2 is linked to pancreatic neoplasm.