CD4 and neoplasm: Even if large quantities of activated T cells are present in various immune organs such as the DLN, antitumor immune responses may still be inadequate for clinical benefit because of inefficient intratumoral infiltration of these activated T cells.27 Thus, the intratumoral infiltration of activated T cells (CD4+IFN-γ+ T cell and CD8+IFN-γ+ T cell subsets of the tumor-infiltrating lymphocytes (TILs)) was evaluated by flow cytometry.