Several tumor microenvironmental factors, which include an abnormal vasculature, elevated interstitial pressure, high cell density, and dense extracellular matrix (ECM), function as the primary barriers against drug penetration.3 Tumor-derived ECM, which consists of a dense network of various collagens, fibronectins, and proteoglycans, inhibits intratumoral penetration and dispersion of therapeutics.4 Thus, determining strategies to breach the ECM is an important goal. The gene discussed is FN1; the disease is neoplasm.