Albeit some similar mechanisms in the induction of chemokines and some inflammatory cytokines were reported here (i.e., upregulation of CCL5, CXCL10, IFNB, IL6, etc.), it is noteworthy that ZIKV AF and ZIKV AS had a much stronger effect on the RPE integrity and homeostasis. The gene discussed is IL6; the disease is atrial fibrillation.