Compared with Dorset group, in HanBB sheep, the genes with up-methylated upstream2k region were associated with valine, leucine and isoleucine biosynthesis; the down-methylated 5′-UTR genes were related to T cell receptor signaling pathway; the genes with down-methylated CDS were involved in ECM-receptor interaction, tight junction, renin-angiotensin system and toxoplasmosis, as well as the up-methylated CDS were also related to ECM-receptor interaction, besides, the pathways of amoebiasis, cysteine and methionine metabolism and protein digestion and absorption were involved. Here, REN is linked to amebiasis.