At baseline, considering the status of the patients as pre-diabetes, we found positive correlations between Let-7a and INSR, Let-7e and IGF1 R, miR-144 and FTO and miR-92a and FTO. It was demonstrated before that Let-7a can regulate the expression of INSR in breast cancer cell lines [47], confirming the function of this miRNA in targeting genes related to IGF signalling pathway [47]. The gene discussed is INSR; the disease is breast cancer.