Although there is a lack of previous studies linking these genetic factors with cognitive dysfunction in fibromyalgia, the relationship between the COMT rs4680 polymorphism and working memory functioning has been consistently reported in healthy volunteers [28,30,31,34,94] and other pathologies characterized by working memory impairments such as schizophrenia or posttraumatic stress disorder [36,37,38,39]. This evidence concerns the gene COMT and schizophrenia.