The Cys protease families include Ub-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCH), ovarian tumor domain proteases (OTUs), Machado–Josephin disease proteases (MJD), motif interacting with ubiquitin novel DUB family (MINDY), and Zinc finger with UFM1-specific peptidase domain protein (ZUFSP), whereas the JAB1/MPN/MOV34 (JAMM) deconjugases are zinc-dependent metalloproteases. Here, ZUP1 is linked to neoplasm.