To simplify, the lymphocyte response in the tumor is subdivided into two opposite functional poles: a Th1 response, usually associated with active tumor recognition and inflammation; and a Th2 response, characterized by an inhibition of Th1 response and mediated by the release of cytokines such as TGFβ, IL4, IL13, and IL10 by monocytes and TAM. The gene discussed is IL4; the disease is neoplasm.