TGFB1 and neoplasm: To simplify, the lymphocyte response in the tumor is subdivided into two opposite functional poles: a Th1 response, usually associated with active tumor recognition and inflammation; and a Th2 response, characterized by an inhibition of Th1 response and mediated by the release of cytokines such as TGFβ, IL4, IL13, and IL10 by monocytes and TAM.