In patients with stages 3 to 4 CKD high ETP (the top quartile, ≥1782.0 nM × min) was only predicted by stage 4 CKD (OR: 7.86, 95% CI: 3.39–18.22, p < 0.0001) and heart failure/LV dysfunction (OR: 0.39, 95% CI: 0.17–0.87, p = 0.02), while other CHA2DS2-VASc score risk factors and NT-proBNP were not associated with high ETP. This evidence concerns the gene NPPB and chronic kidney disease.