Altogether, our data demonstrate that in HD and UC patients the Lactobacillus and Bifidobacterium strains studied in this work interfere with the uptake and persistence of LF82 within dendritic cells, and are all able to interfere with the IL-23/Th17 axis, to a similar extent as the anti-inflammatory drug 6MP, while also stimulating production of the anti-inflammatory cytokine IL-10. Here, IL23A is linked to Huntington disease.