The KM plots of our hub genes shown in Figure 4A–E depicted that higher expression levels of BIRC5 (HR = 1.69; 95% CI = 1.48–1.92; p < 0.05), CCNB1 (HR = 1.67; 95% CI = 1.46–1.91; p < 0.05), KIF4A (HR = 1.68; 95% CI = 1.47–1.92; p < 0.05), KIF11 (HR = 1.44; 95% CI = 1.26–1.65; p < 0.05), KIF20A (HR = 1.58; 95% CI = 1.39–1.81; p < 0.05) worsened the OS in 1725 NSCLC patients. This evidence concerns the gene KIF4A and non-small cell lung carcinoma.