As was observed in a study with Spanish children (aged 3 to 13 years), the rs757228 GPX4 variant was found to be protective factor against obesity and the rs2074451 was associated with increased GPx activity in erythrocytes [15], so our results are in agreement with this previously reported evidence, suggesting a similar effect in this admixed Mexican children population. Here, GPX4 is linked to obesity due to melanocortin 4 receptor deficiency.