Consistently, interrogation of the mRNA levels of Mcl-1 in glioblastomas and normal brain tissue confirmed that glial tumors up-regulated Mcl-1 mRNA in keeping with the emergence of a super enhancer at the Mcl-1 locus and the notion that the epigenetic regulation of Mcl-1 facilitated its increased abundance in glioblastoma as compared to normal brain tissue (Figure 1d). This evidence concerns the gene MCL1 and glioma.