Silencing of ENSRNOG00000037522 reversed the HG-simulated EMT process with decreased expression of α-SMA and vimentin accompanied by a corresponding increase in podocyte-specific protein PODXL1 and nephrin, suggesting that ENSRNOG00000037522 participates in the modulation of podocytes in DN by facilitating EMT [131]. This evidence concerns the gene ACTA1 and liver dysplastic nodule.