The overexpression of lncRNA MEG3 prevents TGF-β1-induced EMT, as shown by the elevated expression of E-cadherin and correspondingly inhibited protein level of N-cadherin and vimentin in HK2 transferred with overexpression plasmids of MEG3, and therefore, rescues TGF-β1-induced renal fibrosis. The gene discussed is MEG3; the disease is renal fibrosis.