MUC5AC and neoplasm: A study with an antibody directed against mucin, conjugated via an acid-labile linker, showed good therapeutic effects in a preclinical pancreatic cancer model [42] where the tumor microenvironment is significantly more acidic than in normal tissues, due to the enhanced glycolysis taking place in the tumor with the consequent production of lactate to a level sufficient to induce extracellular cleavage of the linker.