Figure 6A shows the methylation of cg10627429 and cg11204562 in two patients, one with hypermethylation (96% and 87%) while the other with hypomethylation of two CpGs. The hypomethylated tumor expressed more than 1000-fold higher PLEKHS1 mRNA than did the hypermethylated one (422 vs. 0.41) (Figure 6B). Moreover, the analyses of 35 tumors reveal significantly inverse correlations between PLEKHS1 expression and methylation status of each CpG (cg10627429 and cg11204562, r = −0.396, and −0.428, p = 0.019 and 0.010, respectively) or their combination (r = −0.437, p = 0.009) (Figure 6C). Here, PLEKHS1 is linked to neoplasm.