Specific depletion of phagocytic cells by intraperitoneal injection of clodronate liposomes protected mice from high fat diet-induced obesity, notably by improving insulin sensitivity, glucose homeostasis and inflammatory status, including decreased plasma tumor necrosis factor-α (TNFα) and increased plasma adiponectin (Ad) [16,17]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.