DNMT1 and gastric cancer: Other studies focused on the different DNMT gene polymorphisms, finding conflicting results about possible associations between specific a single-nucleotide polymorphism (SNP) and DNMT activity and prognosis of patients, [85,86,87,88,89,90], with the DNMT1 rs16999593 variant emerging as associated with enhanced risk of GC development in two different meta-analyses [91,92].