Recently, it was demonstrated that upregulated G9a forms a functional complex with p300 and glucocorticoid receptor that induces the expression of ITGB3. Interestingly, G9a catalytic activity is not needed for this effect, but this complex promotes cell invasion and migration in GC cell lines, suggesting that it could be a tumor biomarker for targeted therapy [121]. The gene discussed is EHMT2; the disease is gastric cancer.