Moreover, CNTN1 was identified as a direct downstream molecule of the vascular endothelial growth factor C (VEGFC)-VEGF receptor 3 (VEFGR3)/fms-related tyrosine kinase 4 (Flt4) axis important in lymphangiogenesis and lymphatic invasion in cancers [53,54,55]. The gene discussed is FLT4; the disease is cancer.