For instance, while the VEGFC/Flt4 pathway unregulated CNTN1 expression in lung cancer [53], CNTN1 upregulation in prostate cancer is an outcome of the conversion of non-CSC PC cells to PCSC and CNTN1 in turn contributes to PCSC-derived metastasis [64,122]. This evidence concerns the gene VEGFC and Familial prostate cancer.