Compared to adjacent normal gastric mucosal tissues, both CNTN1 mRNA and protein expression were significantly upregulated in primary lesions and its expression level was positively correlated with VEFGC and Flt4 expression as well as lymphatic invasion, lymph node metastasis, TNM (tumor, node, metastasis) stage and worse prognosis in gastric cancer patients [60]. This evidence concerns the gene FLT4 and gastric cancer.