Further, the intriguing angiogenic role of CD163+ macrophages on the vascular system, as investigated in vessels with atherosclerotic plagues [71] where the macrophages, despite the different pathology compared to cancer, may exert many similar functions to stimulate oxygenation and nutrition of the tissues during the inflammatory process which might contribute to poor prognosis and metastasis. The gene discussed is CD163; the disease is cancer.