Finally, to reconfirm that both miR-96 and miR-449a are under the control of Wnt/β-catenin signaling, we examined whether knockdown of β-catenin or the co-activator CBP could phenocopy the effect of ICG-001-mediated restoration of miR-96 and miR-449a in NPC cells. This evidence concerns the gene CREBBP and nasopharyngeal carcinoma.