In addition, an integrative network-based approach displayed that DAP12/TYROBP is a key regulator of late-onset AD [29] and in another systems biology-based study, using a weighted gene co-expression network analysis, DAP12/TYROBP was among the hub genes of a preserved network that was strongly related to neurodegenerative diseases, but also to aging [30]. The gene discussed is TYROBP; the disease is Alzheimer disease.