RAB5A and Alzheimer disease: Age-dependent Rab5-positive early endosome enlargement and endo-lysosomal dysfunction were observed in an AD-vulnerable brain region of targeted replacement mice expressing the human Apolipoprotein E4 (ApoE4) gene, the dominant genetic factor for the development of late-onset Alzheimer’s disease, under the control of the endogenous murine promoter [82].