To investigate the considerable increase in bilirubin in the proband (tot 5.3, ind 4.9), which was modest in the mother (tot 1.7, ind not available) and brother (tot 1.1, ind 0.9), we carried out the analysis of the UGT1A1 gene, to evaluate the presence of mutations causing Gilbert’s Syndrome [23,24]. Here, UGT1A1 is linked to Gilbert syndrome.