Pathologically misfolded proteins, common in many neurodegenerative diseases, are often found to be concentrated in the amygdala, specifically, it has been shown to be a locus of pathologic synergy Tau, Aβ, α-Synuclein, and TDP-43 misfolding with tropism for the amygdala [5,105]. This evidence concerns the gene MAPT and neurodegenerative disease.