In this study, 6 prognostic mRNAs (TM6SF1, ZMAT1, MANSC1, PYCARD, SLC38A1, and LRRC4) were used as the core foundation to construct a more comprehensive ceRNA regulatory network related to circRNA, lncRNA, miRNA, and mRNA as the target biomarker for AML prognosis prediction. Here, TM6SF1 is linked to acute myeloid leukemia.