These 14 mRNAs were further analyzed by multivariate Cox proportional hazard regression analysis, and 6 hub mRNAs were selected to predict the prognosis of AML: TM6SF1, ZMAT1, MANSC1, PYCARD, SLC38A1, and LRRC4 (Table 4). This evidence concerns the gene LRRC4 and acute myeloid leukemia.