The group of these osteosarcoma inducers (the first driver) includes TP53, NOTCH1, MYC, FOS, NF2, WIF1, BRCA2, APC, PTCH1 and PRKAR1A. However, the potential to induce osteosarcoma in each of the above genes is different. Here, PTCH1 is linked to osteosarcoma.