The crucial role of MMP-2 in AML was the subject of a study by Sawicki et al. They prepared a human leukemic cultured KG-1 cell line and examined the role of MMP-2 in in vitro invasion by leukemic cells, by using recombinant human TIMP (rhTIMP) and anti-MMP-2-antibody. The gene discussed is MMP2; the disease is acute myeloid leukemia.