EZR and neoplasm: Other parameters associated with decreased OS on univariate analysis included tumor multiplicity (HR, 2.81; 95% CI, 1.49–5.31; p = 0.001), tumor size (≥5 cm vs. <5 cm) (HR, 2.40; 95% CI, 1.32–4.38; p = 0.004), portal vein invasion (HR, 3.29; 95% CI, 1.39–7.80; p = 0.007), the presence of extrahepatic metastasis (HR, 4.46; 95% CI, 2.45–8.13; p < 0.001), and expression of CAIX (HR, 1.85; 95% CI, 1.02–3.39; p = 0.044) and ezrin (HR, 3.16; 95% CI, 1.67–5.97; p < 0.001).