Multivariate analysis revealed cytoplasmic Nrf2 expression to be a significant independent prognostic factor for OS (HR, 4.35; 95% CI, 2.11–8.97; p < 0.001), along with tumor multiplicity (HR, 1.98; 95% CI, 1.02–3.86; p = 0.045), presence of extrahepatic metastasis (HR, 3.75; 95% CI, 1.91–7.36; p < 0.001), and ezrin expression (HR, 2.41; 95% CI, 1.25–4.64; p = 0.009) (Table 3). The gene discussed is EZR; the disease is neoplasm.