A subset of HCCs that are morphologically compatible with HCC but express immunohistochemical markers associated with stemness (e.g., K19, EpCAM, and SAL-like protein 4 (SALL4)) recently received increasing attention, as these HCCs demonstrate more aggressive behavior compared to conventional HCCs, expression of EMT-related markers, poor prognosis, and resistance to locoregional and systemic treatment [23,24,25]. The gene discussed is SALL4; the disease is hepatocellular carcinoma.