TP53 and hepatocellular carcinoma: The genomic landscape of HCC was unraveled during the past decade, with the most common genetic alterations being mutations in TP53, CTNNB1, and TERT promoter genes [2,3,4]; following the identification of distinct morphological subtypes of HCCs that partly correlate with the molecular features, there was increasing interest in the heterogeneity of HCC in recent years [5].