As it is the nuclear form of Nrf2 that is recognized to be the active pro-tumorigenic form, we also examined nuclear pNrf2 expression in HCC, and we found that pNrf2-high HCCs were associated with poor prognosis, increased proliferative activity, and more frequent expression of markers associated with stemness, EMT, and hypoxia. Here, NFE2L2 is linked to hepatocellular carcinoma.