DNMT1 and lung carcinoma: Similarly, the work of Lin et al. indicates that overexpression of DNMT1 causes abnormal regulation of the p53/Sp1 pathway, resulting in hypermethylation of multiple TSGs (p16, RARβ, FHIT, RASSF1A and hRAB37), and eventually leading to the occurrence of lung cancer with poor prognosis [35].