The activation of STAT3 through Tyr-705 phosphorylation is known to be transient in CLL cells (from 5 min to 15 h) [37], which can explain that the relative levels of pY705-STAT3 in CLL cells at 24 h of culture were found to be similar in NGAL- and IFN-γ-treated cells and in untreated cells (Figure 6D). This evidence concerns the gene STAT3 and B-cell chronic lymphocytic leukemia.