Together with the stimulation of the nuclear factor kappa-light-chain enhancer of activated B cell (NF-κB) signaling, stromal uPA activates matrix metalloproteinase-2 (MMP-2) production and becomes responsive on the surface of tumor cells to cleave any component of the ECM, thereby allowing a break through the basement membrane and facilitating the EMT process [104,105]. This evidence concerns the gene MMP2 and neoplasm.