The measurement of CRP, interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, tumor necrosis factor alpha (TNFα)-R1, adiponectin, resistin, and leptin revealed that high levels of cytokines increase the likelihood of MetS in obese and non-obese individuals, irrespective of insulin resistance. The gene discussed is CRP; the disease is Insulin resistance.