We analyzed prognostic significance of molecular-cytogenetic aberrations of seven genes (TP53, CDKN2A, ATM, BCL2, MYC, RB1, and CDK4) using FISH in 126 consecutive patients with newly diagnosed MCL with BM involvement ≥5% between 1 January 2009 and 30 June 2018 at the Center of Oncocytogenomics, General University Hospital in Prague (Figure 1). This evidence concerns the gene CDK4 and mantle cell lymphoma.