TNF and Nephroblastoma: Therefore, the upregulation of heme and ROS due to a decreased HO activity increases pre-adipocyte differentiation, as well as adipogenesis and the release of inflammatory adipokines such as nephroblastoma overexpressed gene (NOV), tumor necrosis factor-α (TNFα), and Interleukin-6 (IL-6) [11,12,13].