Thus, taken together, our results suggested that the TEG derivatives TD-10 and TD-11 have multimode actions: in addition to the targeting of VEGF and MMPs, they possess the potential to transcriptionally suppress mortalin and MMP-9, leading to the reversal of EMT and epithelialization of the metastatic cancer cells. This evidence concerns the gene MMP9 and metastatic malignant neoplasm.