VEGFA and cancer: The VEGF gene is located on human chromosome 6, and the protein is expressed abundantly in almost all cancer and few endothelial cells, in response to stimuli such as hypoxia, hypoglycemia, growth factors/cytokines (EGF, FGF, IGF, TGF-β, activin A, IL6, TNF-α) and oncogenes (p53, NFκB, Wnt, TIMP and FAK) [16].