Cancer cells at the primary site get triggered by pro-migratory factors such as Wnt/β-catenin, hypoxia or TGF-β and undergo epithelial-to-mesenchymal transformation (EMT); these cells lose surface adhesion proteins (such as E-cadherin, ZO-1 and Laminin) and gain mesenchymal proteins (such as N-cadherin, vimentin and matrix metalloproteinases) [8,9]. This evidence concerns the gene VIM and cancer.