As shown in Figure 3A, hypermethylation of the PLA2R1 promoter was detected in triple negative (HCC1395, HCC1187, DU4475, KPL1 and BT20) and HER2-positive (SKBR3, HCC202 and HCC1954) breast cancer cell lines [19]. The gene discussed is PLA2R1; the disease is breast cancer.