Non-significant hypermethylation of PLA2R1 promoter was detected in HER2-positive (fold change= 1.033, p = 0.07), luminal A (fold change = 0.871, p = 0.5) and luminal B (fold change =1.03, p = 0.5) breast cancers (Figure 3D). This evidence concerns the gene ERBB2 and breast cancer.