The miR-409-3p/5p-dependent depletion of RSU1 occurs following the epithelial uptake of stromal-produced exosomes in early prostate tumors; the use of miR-409 antagomiRs restored the RSU1 protein and decreased bone metastasis in a mouse model of aggressive prostate cancer [15,16]. Here, RSU1 is linked to prostate carcinoma.