Therefore, the observation that the exosome-mediated miR-induced depletion of RSU1 correlates with the tumor initiation and metastasis in prostate cancer, and that RSU1 expression is altered between normal and tumor tissue in breast tumors [59], supports a role for miR regulation of the RSU1 function in breast tumor development and/or progression. Here, RSU1 is linked to Familial prostate cancer.