CD28 and Miyoshi myopathy: Therefore, understanding the mechanism by which CD28 activation by the extrinsic bone marrow microenvironment is able to drive a cell intrinsic program of LLPC/MM survival would advance the field by allowing us to understand the extrinsic interactions in the BM that govern cell intrinsic programs of survival in order to augment vaccine design, alleviate autoimmunity, and treat MM.