Therefore, determining the role of the different Ub genes and of the transcription factors (YY1, HSF1 and SP1) known to be involved in Ub gene expression, both in primary and metastatic GC cells, can pave the way for future studies aimed at identifying new biomarkers involved in the carcinogenetic process that leads to the development of gastric adenocarcinoma. The gene discussed is SP1; the disease is gastric cancer.