Our results demonstrate the role of UBB and UBC as pro-survival genes in primary GC cell line 23132/87 and show that the combined silencing of these two Ub genes in the primary gastric adenocarcinoma cells led to a decrease in their viability, exerted through activation of the extrinsic pathway of apoptosis, and a reduction in levels of the oncoprotein β-catenin, which has a role in overproliferation, migration, invasion of various tumors and also in the epithelial to mesenchymal transition (EMT) process [30]. The gene discussed is UBB; the disease is gastric cancer.