CASP8 and neoplasm: Interestingly, Zhang et al. have demonstrated, in several cancer cell lines, that the oncoprotein Cysteine-rich intestinal protein 1 (CRIP1) can interact with Fas, enhancing its ubiquitination and degradation and leading to inhibition of caspases 8 and 3, thus underlining the tumor suppressor role of this transmembrane protein [52].