In addition, Tang et al. [10] demonstrated that the knockdown of UBB and UBC in A549 lung cancer cells led to a reduction in cancer cell viability, activation of the intrinsic pathway of apoptosis, decrease in NF-kB and p-Akt levels (after irradiation treatment) and reduction in the volume of A549-derived xenografts. Here, NFKB1 is linked to lung cancer.