FN1 and neoplasm: Our data are in line with findings in several cancer cell models, in which it is now well established that both the generation of biologically active ECM fragments via ECM degradation as well as fibronectin deposition provide critical biomechanical and biochemical cues that guide the homing and arrest of bone marrow derived cells and circulating tumor cells to PMNs thereby promoting metastasis [24,25,26].