A relatively new but interesting target structure for the design of heterobivalent agents is neuropilin-1 (NRP-1), which interacts with the VEGFR as a co-receptor and is correlated with the vascularization, progression, and metastasis of different cancers such as glioma, prostate, breast, colon, and lung cancers [131]. The gene discussed is NRP1; the disease is lung cancer.