Though suggesting a contribution of the TXNIP [153,154], PR2X4 [155], and HMGB1/TLR4-NLRP3 signaling pathways [156], these studies do not provide conclusive evidence on the role of NLRP3 in diabetic neuropathy and need to be confirmed in larger controlled studies. The gene discussed is NLRP3; the disease is diabetic neuropathy.