In addition to hyperglycemia-induced ROS overproduction, oxidized LDLs (oxLDLs) [58] and high mobility group box Protein 1 [59], two well-known agonist ligands of the receptor of AGEs (RAGE) [60,61], have been involved in the activation of NLRP3 that accompanies the atherosclerotic process. The gene discussed is NLRP3; the disease is Hyperglycemia.