CASP1 and diabetic kidney disease: Moreover, the transplantation of Nlrp3- or caspase-1-deficient bone marrow (BM) cells failed to ameliorate albuminuria and mesangial expansion in wild type diabetic mice, whereas Nlrp3-/- diabetic mice maintained protection from DKD despite transplantation of wild type BM cells, indicating that the Nlrp3 inflammasome in renal resident cells, particularly podocytes and glomerular endothelial cells, is the main contributor to the pathogenesis of DKD [9] (Figure 4).