Figure 1A shows a typical example of a patient with enhanced staining of EphB4 in tumor epithelial cells and low staining for corresponding normal tissue. Figure 1B shows a particular case with more staining in normal tissue than corresponding tumor tissue. For scoring of the staining’s, the mouse monoclonal antibody sections were used for both TMAs. The staining of all tissues was scored by two independent examiners, showing a strong correlation (kappa = 0.824, p = 0.001). This evidence concerns the gene EPHB4 and neoplasm.