By using SWATH (sequential window acquisition of all theoretical mass spectra) label-free proteomics, Braccia et al. [47] identified 154 proteins dysregulated by the CF pathology (94 upregulated and 60 downregulated), including known CFTR interactors (such as CHIP) as well as proteins not previously known to be related with CF. Here, CFTR is linked to cystic fibrosis.