Multivariate Cox proportional hazard regression analysis showed that TERT promoter mutations (HR = 5.23, 95% CI 2.33–12.78, p < 0.001), age ≥55 years (HR = 2.47, 95% CI 1.09–6.38, p = 0.030), tumor size >4 cm (HR = 3.90, 95% CI 1.89–8.42, p < 0.001), N1b (HR = 3.27, 95% CI 1.30–8.82, p = 0.011) and M1 (HR = 2.46, 95% CI 1.17–5.15, p = 0.018) were independent risk factors associated with mortality (Table 5). Here, TERT is linked to neoplasm.