Uchida et al. reported a case of an ACC presenting with mild primary aldosteronism and subclinical Cushing’s syndrome, in which CYP11B1, CYP11B2 and 3-β-hydroxysteroid dehydrogenase were poorly expressed as detected by immunohistochemistry and varied across different areas of the tumor. This evidence concerns the gene CYP11B1 and primary aldosteronism.