CYP11B1 and Cushing syndrome due to macronodular adrenal hyperplasia: Sasano et al. described that ACC presented a disorganized pattern of steroidogenic enzyme expression, while non-functioning ACCs were devoid of CYP11B1 and CYP17A1 and depicted lower levels of expression of other enzymes (21-hydroxylase, 3-β-hydroxysteroid dehydrogenase and CYP11A1) as compared to functioning ACC presenting with Cushing’s syndrome [16].