The aim of this study was to analyze the expression of four key proteins involved in adrenal steroidogenesis, namely steroidogenic acute regulatory protein (StAR), 11β-hydroxylase (CYP11B1), aldosterone synthase (CYP11B2), and 17α-hydroxylase (CYP17A1), in different adrenocortical tumors in order to understand the potential utility of these molecular markers for diagnosis in a clinical setting. Here, STAR is linked to adrenal cortex neoplasm.