In the second case, mAB can be useful tools for the handling of tumor microenvironment, i.e., interrupting the interactions between ligands and their receptors (EGF, endothelial growth factor; vascular endothelial growth factor, VEGF; etc.), or promoting the recruitment of the immune system, in order to facilitate a direct and specific attack to cancerous cells. The gene discussed is VEGFA; the disease is neoplasm.