CTRC and acute kidney injury: The CLR values of tofacitinib were faster than their respective CLCRs in control and G-ARF rats, but CLRs of tofacitinib and CLCR in C-ARF rats were comparable each other, suggesting that tofacitinib is mainly excreted in urine via active secretion for control and G-ARF-rats [12,18,24] and in glomerular filtration for C-ARF rats.