Although the lack of a procedure that allows the selective detection of pAPP-Tyr682 in neurons insinuates that Fyn might influence the phosphorylation also of other Tyr(s) on the APP sequence rather than Tyr682, these results clearly emphasize the upstream role of APP Tyr682 phosphorylation in the APP amyloidogenic processing and the possibility to targeting Fyn for the development of new therapeutic strategies in AD. The gene discussed is FYN; the disease is Alzheimer disease.