To determine whether promoter methylation of the LMX1A gene is a common epigenetic event in non-small cell lung cancer, we first used DNA methylation data from the SMART App (http://www.bioinfo-zs.com/smartapp) [34] to analyze the methylation levels of LMX1A in 458 lung adenocarcinoma (LUAD) and 364 lung squamous cell carcinoma (LUSC) samples. Here, LMX1A is linked to lung adenocarcinoma.